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Weight Loss Surgery Research Study 
Bone Metabolism in Adolescents Undergoing Bariatric Surgery
A study for 13-25 year old males and females with obesity


Study Aim

The Neuroendocrine and Pediatric Endocrine Units and Department of Radiology at the Massachusetts General Hospital would like to learn about the effect of weight-loss surgery on bone outcomes in teenagers and young adults.


We have enrolled girls and boys ages 13-25 who have overweight and are being considered for weight-loss surgery (Roux-en-Y gastric bypass or Vertical Sleeve Gastrectomy). We are also currently enrolling girls and boys ages 13-25 who are not scheduled or planned for surgery.

Please note, as of Fall 2021, we are only recruiting individuals who are being considered for Roux-en-Y gastric bypass surgery.

Adults with obesity who undergo weight-loss surgery are at risk for bone loss and decreased bone strength. We do not know the effects of such surgery on bone in teenagers and young adults. We are doing this research study to find out how different types of weight loss surgery affect bone density and strength in teenagers and young adults and to compare these results to teenagers and young adults who are not undergoing weight-loss surgery. We also want to study the amount of fat in the body and within bones as well as markers in the blood that may be responsible for bone loss.



If you are eligible and interested in the study, we will contact you to schedule a screening visit. This visit will help us determine if you are eligible beyond what we can learn from you over the phone. 

Study Coordinators: 

Carolyn Huynh


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Meghan Lauzé


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Research Fellows:

Supritha Nimmala, MBBS

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Snimarjot Kaur, MD

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Fatima Cody Stanford, MD, MPH, MPA
Vibha Singhal, MD
Principal Investigators:

Madhusmita Misra, MD, MPH

Miriam Bredella, MD

Study Visits
Total Compensation up to $2100
Initial Screen Visit
History, physical exam, blood work 
Determine eligibility & interest in study
Visit length: about 2 hours


Baseline, 12, and 24 Month
DXA Scan, CT Scan, MRI scans
History, Physical, and Blood work
Visit length: about 6 hours


6 and 18 Months
History, physical exam, and blood work 
Visit length: 40 minutes