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Weight Loss Surgery Research Study 
Bone Metabolism in Adolescents Undergoing Bariatric Surgery
A study for 13-25 year old males and females with obesity


Study Aim

The Neuroendocrine and Pediatric Endocrine Units and Department of Radiology at the Massachusetts General Hospital would like to learn about the effect of weight-loss surgery on bone outcomes in teenagers and young adults.


We have enrolled girls and boys ages 13-25 who have overweight and are being considered for weight-loss surgery (Roux-en-Y gastric bypass or Vertical Sleeve Gastrectomy). We have enrolled girls and boys ages 13-25 who are not scheduled or planned for surgery.

Please note, recruitment is now closed for this study.

Adults with obesity who undergo weight-loss surgery are at risk for bone loss and decreased bone strength. We do not know the effects of such surgery on bone in teenagers and young adults. We are doing this research study to find out how different types of weight loss surgery affect bone density and strength in teenagers and young adults and to compare these results to teenagers and young adults who are not undergoing weight-loss surgery. We also want to study the amount of fat in the body and within bones as well as markers in the blood that may be responsible for bone loss.

Recruitment is now closed for this study. However, if you are interested in participating in a future study, you are welcome to complete this eligibility survey. A staff member will contact you if you are eligible for a future study.

Study Visits
Total Compensation up to $2100
Initial Screening Visit:
Visit length: about 2 hours
  • History, Physical Exam, and Bloodwork

  • Determine eligibility & interest in study

Baseline, 12, and 24 Month:
Visit length: about 6 hours
  • History, Physical, and Bloodwork

  • DXA Scan, CT Scan, MRI Scans

6 & 18 Month:
Visit length: about 40 minutes
  • History, Physical, and Bloodwork
Study Coordinator: 

Meghan Lauzé


Click here to email

Research Fellows:

Imen Becetti, MD

Ana Lopez, MD

Shubhangi Tuli, MBBS

Fatima Cody Stanford, MD, MPH, MPA
Vibha Singhal, MD
Principal Investigators: 

Madhusmita Misra, MD, MPH

Miriam Bredella, MD

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