Pediatric Endocrine-Neuroendocrine-Sports Endocrine Research
Improving Health Through Research
In Conjunction with the Eating Disorders Clinical and Research Program (EDCRP) at Massachusetts General Hospital
REACT Study
Restrictive Eating and Athlete Cognition Trial
A study for 14-35 year old females with restrictive eating and/or athletes who have missed periods in the last 6 months
Study Aim
Research has shown that females with eating disorders have lower levels of estrogen, leading to irregular or missed periods. Estrogen is involved in mental flexibility and reward responsiveness. This study aims to investigate whether replacing estrogen levels in young females with restrictive eating and/or athletes who have irregular periods will improve mental flexibility and reward responsiveness.
The study will be 4 months long and will include 4 visits: a screening visit, a baseline visit, an 8 week visit, and a 12 week visit.
Study Visits
Total Compensation up to $525
Initial Screening Visit:
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History, Physical, and Bloodwork
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Psychological assessment
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Brief questionnaires
Baseline:
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History, Physical, and Bloodwork
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Behavioral interview
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Brief questionnaires
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Neuroimaging MRI scans
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Computer tasks
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Food diary
8 Week Visit:
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History and Bloodwork
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Brief questionnaires
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Neuroimaging MRI scans
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Computer tasks
12 Week Visit:
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History, Physical, and Bloodwork
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Behavioral interview
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Brief questionnaires
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Neuroimaging MRI scans
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Computer tasks
If you are eligible and interested in the study, we will contact you to schedule a screening visit. This visit will help us determine if you are eligible beyond what we can learn from you over the phone.
Interested in learning more?
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A few past participants kindly shared their experiences with us, which you can read here: Participant 1 & Participant 2
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Click here to view some of our study clinicians discuss how restrictive eating can impact the brain and body.
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Click here to read about one coach's new approach to training female athletes.
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Click here to listen to a podcast about female Olympians and Paralympians from Harvard Kennedy School's Women and Public Policy Program.
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Click the box below to read more about our unit's research.
Study Coordinators:
Meghan Lauzé
617-643-4034
Felicia Petterway
617-724-6046
Macy Turley
617-643-7847
Principal Investigators:
Kamryn Eddy, PhD
Madhu Misra, MD MPH
Poornima Kumar, PhD
(Site PI; McLean Hospital)
Co-Investigators:
Franziska Plessow, PhD
Jennifer Thomas, PhD
Elizabeth Lawson, MD
Lauren Breithaupt Langston, PhD
Diego Pizzagalli, PhD
(McLean Hospital)
617-643-0267